Línea de tiempo 1492 03 August 1492 Columbus's First Voyage (1492) 03 August 1492 Logbook of the First Voyage 12 October 1492 The Discovery (1492) 1493 01 June 1493 The First Mestizos of Spanish America 25 July 1493 Columbus's Second Voyage (1493-1496) 1498 30 May 1498 Columbus's Third Voyage (1498-1500) 01 June 1498 The Great Food Exchange between the Americas and Europe 1499 10 October 1499 Amerigo Vespucci, Alonso de Ojeda and Juan de la Cosa Explore the Coast of Venezuela and Brazil 1500 10 October 1500 Vicente Yáñez Pinzón: Navigator of the Amazon and Pioneer of Brazil 1502 01 January 1502 1502–1533: Atahualpa 02 February 1502 The Carib People 03 February 1502 The Taíno People 09 May 1502 Columbus's Fourth Voyage (1502-1504) 1513 01 January 1513 Vasco Núñez de Balboa Crosses the Isthmus of Panama and Discovers the Pacific Ocean 1518 10 October 1518 1518–1521: The Conquest of the Mexica Empire 1520 01 January 1520 1466–1520: Moctezuma II 1521 11 October 1521 1521-1600: The Creation of New Spain 30 October 1521 1325–1521: The Mexica Empire 1524 01 June 1524 The Arrival of the Twelve: A Dawn for Spanish America 01 July 1524 The Conquest of Guatemala and El Salvador (1524–1530): A Complex and Transformative Process 1525 01 January 1525 1497–1525: Cuauhtémoc 1526 01 January 1526 1500–1526: Malintzin 1529 01 June 1529 1478–1541: Francisco Pizarro 1530 01 July 1530 The Conquest of the Inca Empire (1532–1533): When the Sun Fell 1574 01 June 1574 The Santa Hermandad in Spanish America